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The mutation L234F in combination with the S239C mutation reduced FcR binding

Inhibition of GOT1 sensitized the cancer cells to glucose deprivation, which was partially counteracted by metabolic intermediates downstream of GOT1 like OAA and phosphoenol pyruvate

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These defects appear to get progressively worse with increasing age, and the oldest patients with COVID-19 had higher level of defects in these outcomes