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G6PD deficiency impairs redox control and increases susceptibility to oxidative damage and hemolysis (Luzzatto et al., 2020)

10.26355/eurrev_202012_24046 Eur Rev Med Pharmacol Sci

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Oral dosing introduces variability that makes dose-response relationships harder to establish

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In vivo experiments confirmed that the MPO/HOCl signaling pathway was significantly activated in the plasma and neurons of SOD1 G93A transgenic mice, which upregulated Caspase-3 expression, downregulated GPX4 and NQO1 expression, significantly elevated plasma MDA levels, promoted neuronal apoptosis, ferroptosis, and lipid peroxidation, and reduced motor performance in mice (Peng et al., 2022)