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doi: 10.1038/s41537-024-00485-x 85 LiC.ZhangL.LiX.HuQ.MaoL.ShaoY.et al

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Specifically, it has been suggested that the calcium-independent enzymes (iPLA 2 ) contribute to cytosolic oxidant production in skeletal muscle cells (140), while a 14kDa calcium-dependent isoform (sPLA 2 ) located within mitochondria has been reported to stimulate intracellular ROS generation during contractile activity (282)