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Met is first metabolized by methionine adenosyltransferase (MAT) to form S-adenosylmethionine (SAMe, which is also abbreviated as AdoMet) (Figure 1)

doi: 10.1186/s13578-022-00764-z 84 LiuTJiangLTavanaOGuW

Histone methylation usually compacts the DNA, restricting the access of transcription factors necessary for gene expression

Epithelial cell and lamina propria isolation Single-cell suspensions of small intestinal epithelium and lamina propria were prepared as described previously 69,70

Brain iron accumulation affects myelin-related molecular systems implicated in a rare neurogenetic disease family with neuropsychiatric features