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16 , by addressing the dose-dependent properties of mainstream tobacco smoke exposure on allergic response, highlighted the exposure regimen as a critical parameter in the outcome of cigarette smoking on the asthmatic phenotype in these models

The number one complaint of new pipe smokers seems to be that they do not know how to correctly 'pack' their pipe, resulting in either dottle left over at the end of the smoke, or a hot smoke and the dreaded tongue bite, or a pipe that is hard to draw on