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Peer review Peer review information Nature Cell Biology thanks Qingran Kong and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Peroxynitrite can initiate DNA damage, leading to the stimulation of a nuclear enzyme, poly (ADP-ribose) synthase (PARS), which causes a decrease in cellular energy levels and leads to cell death

The starting dose of probenicid is usually 250 mg twice daily but it may need to be increased to up to 1 g twice daily

B12 injections may also help with depression and increment red blood cell production

slow titration and moisturizer use lessen severity