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Critically, impaired mitochondrial energetics are an early pathogenic event in Smyd1 -KO hearts preceding structural remodeling, which is correlated with significantly reduced expression of the key metabolic regulators PGC-1, PPAR, and retinoid X receptor alpha (RXR)

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nucleatum could increase osteoclast differentiation via increased expression of IL-17A and TNF-alpha (161)

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