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According to study by Shuja et al .,[] Jing et al .,[] and Hamadi et al .,[] levels of plasma GSH levels were found to be significantly decreased in cases of melasma when compared with controls

Using mouse embryonic fibroblasts (MEFs) and human malignant melanoma cells treated with active-site mTOR inhibitor (asTORi), was demonstrate that mTORC1 stimulates the translation of MTFP1 mediated by 4E-BP, and therefore the mTOR inhibition induces the phosphorylation of the DRP1 at Ser 637, this phosphorylation prevents it translocation to mitochondria, conversely, the pro-fission phosphorylation site of DRP1 at Ser 616 was decreased in asTORi treated cells

The role of mitochondrial DNA in mediating alveolar epithelial cell apoptosis and pulmonary fibrosis

doi: 10.1038/s41419-019-2143-7 130 YouJHLeeJRohJL