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This highlights the potential risks of overthecounter dietary supplements, which may not have undergone systematic safety assessments

Large-scale prospective clinical trials conducted in CD patients have found that supplementation with PUFA may worsen IBD symptoms, indicating disrupted gut homeostasis [294]

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Sustained microglial activation leads to the release of pro-inflammatory cytokines such as TNF-, IL-1, and IL-6, which exacerbate neuronal injury and amplify amyloid and tau pathology (Kaur et al., 2019)

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