l-carnitine shuttles fatty acids into mitochondria Carnitine Shuttle transport of fatty acids |

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For extraction of intracellular metabolites, cells were washed on ice with 1 mL ice-cold 150 mM ammonium acetate (NH 4 AcO, pH 7.3)

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doi: 10.1172/jci.insight.152611 100 KangHLiXZhouQQuanCXueFZhengJet al

In the early stages of metastasis, autophagy primarily inhibits the EMT programme, and later, metastatic cells may require sustained autophagy for survival under environmental and metabolic stress conditions (111) ( Figure 4 )

Funding This research was supported by the National Institutes of Health Grants: R01-DK088139 (PJR), R01-HD093701 (PJR), T32HD007186 (JS, AW trainees, PJR PD), R01-HD079404 (LDB)