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UV radiation exposure indirectly initiates MMP activation without upregulating collagen production, causing decreased collagen levels and ECM fragmentation (72)

Jun 2021;225(3):226-231

L., Elmquist, W

Consistent with these reports, we observed elevated ATF4 levels in intestinal cell lines after metformin treatment (Supplementary Fig

Most cases are asymptomatic, but they can cause loss of vision in up to 12% of patients37 or provoke early onset of puberty.35 In view of the high incidence of ONGs, close ophthalmological follow-up is advisable in children with NF1, whether this is clinical or radiological, as clinical detection by physical examination can be difficult and some neuropediatricians prefer conducting complementary tests (Fig