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38 For instance, when a plaque obstructs 7080% of a coronary vessel, shortness of breath and chest pain (angina), especially with exertion, may occur

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O may also be secondary to the enzymatic activity of lipoxygenases (LOX) and cyclooxygenases (COX) (Valko et al., 2007) during the arachidonic acid metabolism and by endothelial and inflammatory cells ( may participate in reactions that produce H 2 O 2 or OH (Kumar and Pandey, 2015) (Figure 1)

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