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Simultaneously, targeting gut microbiota dysbiosis and metabolites like TMAO emerge as promising adjunct approaches to ameliorate both autoimmune dysregulation and atherosclerosis in SLE

However, the overall prognosis may depend upon the severity of the signs and symptoms of any underlying disorder it is associated with Who gets Melanotic Macules

These conditions digestive conditions, such as Crohns disease and ulcerative colitis autoimmune conditions, such as celiac disease and type 1 diabetes genetic conditions, such as inherited intrinsic factor deficiency and inherited transcobalamin deficiency chronic pancreatic disease pernicious anemia vitiligo Other factors that may lead to a vitamin B12 deficiency can include drinking excessive amounts of alcohol or using certain drugs, such as some heartburn medicines and metformin