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What is measured in these rats and mice (and occasionally in small groups of human volunteers) is often not a hard endpoint like muscle strength or weight loss, but surrogate biomarkers: molecules in the blood that have an indirect link to a hard endpoint

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While the specific details of the ECD interface of Cagri-AMY 3 R could not be determined due to the low-resolution maps, these findings are indicative of substantial loss of RAMP3/CTR ECD interface interactions and considerable dynamic motions within the RAMP3 and CTR ECD protomers (Fig

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