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Pore collapse underlies irreversible inactivation of TRPM2 cation channel currents

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For Figure 3A to 3C, skin tissues from the three-week dietary supplementation study were used (n = 10 per group)

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Comparison of [s 2 Urd+H] + to Studies of Neutral 2-Thiouridine Previous studies of neutral 2-thiouridine by NMR [42, 44, 45], crystallography [43], and electronic structure calculations [73, 74] all indicate a preference for C3- endo sugar puckering