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A key player is nitric oxide (NO) , which helps blood vessels relax and fill the penis with blood

doi: 10.5935/1518-0557.20200017 14 MeizelSLuiCWWorkingPKMrsnyRJ

Figure 11 Autoimmunity Upregulation of autoimmune genes As in other chronic disorders, some genes in ME/CFS patients have been found to be associated with autoimmunity, such as the HLA alleles (88), along with two other variants of HLA-DQB1 in combination with two RAGE-374A variants (489) was found

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An association with numerous risk factors including age, diabetes mellitus, dyslipidaemia, hypertension, CVD, obesity, MetS, hyperhomocysteinemia, lack of exercise, smoking and drug use has been reported [255,258-269]