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Both trolox and BHT are phenolic antioxidants, while Fer-1 contains an aromatic amine

However, the role of Parkin in APAP hepatotoxicity is uncertain as acute Parkin knockdown exacerbates APAP-mediated liver injury while chronic deletion using knockout mice results in resistance to APAP hepatotoxicity, most likely due to compensatory mechanisms that remain to be further characterized (Williams et al., 2015)

doi: 10.1016/S0140-6736(80)90886-7 63

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doi:10.3390/pharmaceutics17030385 2 Yin N, et al