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Uncontrolled hyperglycemia with persistent ROS generation leads to apoptosis of several types of cells, including epithelial cells of the proximal tubule, damaging the nuclear DNA and mitochondria's genetic material that promotes loss of kidney function

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We hypothesize that this mutation could promote a more stable interaction of KEAP1 with Cul3, increasing NRF2 degradation and explaining the lower levels in this cell line

Regulation of IL-6/STAT-3/Wnt axis by nifuroxazide dampens colon ulcer in acetic acid-induced ulcerative colitis model: novel mechanistic insight

A., Bush, A

10.7554/eLife.04883 Elife 125 PariskyK