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SGLT2i could inhibit aberrant glycolysis (163)

Whereas excessive NO and nitrosative stress may result in airway injury, GSNO is an endogenous bronchodilator associated with airway smooth muscle relaxation (79) that protects against methacholine-induced airway hyperresponsiveness (98, 261) and NF-B activation during allergic airway inflammation (244)

Given the heterogeneity of conditions underlying NPP, there is remains a notable scarcity of therapeutics that directly target non-neuronal cells implicated in NPP mechanisms, with cannabinoid receptor agonists being one of the few exceptions

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After decapitation, the RL4,5,6-DRG and L5-SC were extracted and fixed in 4% paraformaldehyde in 0.1 M phosphate buffer (pH 7.4)

5h and Supplementary Fig