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Long exposure to high glucose concentration impairs the responsive expression of -glutamylcysteine synthetase by interleukin-1beta and tumor necrosis factor-alpha in mouse endothelial cells

Conti, L

Disulfide linker-based ADC strategies rely on higher concentrations of reducing molecules such as glutathione in the cytoplasm (1-10 mmol/L) compared to the extracellular environment (~5 mol/L in blood)

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Further studies using knockout animals indicate that at least in rodents peroxiredoxin 2 and glutaredoxin 1 are the major enzymes detoxifying endogenous H 2 O 2 in RBC (Lee et al., 2003