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However, long-term BG00011 exposure induced acute exacerbations and inflammation, leading to reduced survival rates, and the drug was ultimately discontinued from clinical development ( Given these setbacks in novel drug development, alternative strategies such as drug repurposing have gained traction in IPF research

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In vascular smooth muscle cells, PKC activation has been shown to modulate growth rate, DNA synthesis and growth factor receptor turnover

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Nanoenzymes that can simulate the catalytic process of natural antioxidant enzymes has also been a research hotspot

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