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Notably, GSH binding motif is not conserved among the other seleno-GPxs (GPx2, GPx3, GPx4, and GPx6) justifying their abilities to use wide variety of thiols like cysteine, protein thiols, mercaptoethanol, and dithiothreitol in addition to GSH as reducing equivalent for the catalysis [8, 17, 18]

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And Joe was telling me that he used to eat

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Eventually, this phenomenon became known as the Jarisch-Herxheimer reaction. Over the years, patient communities have adopted a shortened version of the full name, calling them Herxheimer reactions, which Ill use moving forward, or herxes. The reaction tends to happen in people with spirochetal infections, such as Lyme disease, relapsing fever, and others, when theyre treated with antibiotics, according to a medical review in StatPearls