PC-6 dbco-propionyl CP-DOTA-tris(t-Bu) is a SNAP-tag substrate

CP-DOTA-tris(t-Bu) is a SNAP-tag substrate containg a precursor of the macrocyclic chelator DOTA

S wild type cells

Regulatory Statemen: For Research Use Only

Product Name 4-(methoxy-d3)benzoic acid Synonyms 4-(²H3)methoxybenzoic acid CAS Number 27914-54-1 Related CAS Molecular Formula C8H8O3 Molecular Weight 155

626 SMILES: CN(C)C1=CC=C2C(OC3=CC(C=CC3=C2C2=CC(=CC=C2C([O-])=O)C(=O)NCCCCCN)=[N+](C)C)=C1 Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

PC-6 dbco-propionyl CP-DOTA-tris(t-Bu) is a SNAP-tag substratePC 6 is a specially designed fluorescent probe for detecting SARM1 activity, built by conjugating a styryl donor group to a pyridine acceptor to form a donoracceptor system. It functions through SARM1s base exchange reaction, where PC 6 is converted into a positively charged product (PAD6) upon incorporation into NAD, leading to strong intramolecular charge transfer and a large fluorescence shift (from ~430 nm to ~520 nm). Among a series of related