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Appl Microbiol Biotechnol 104:77457766

The anti-calcific effect of zinc on human valve interstitial cells (hVIC) calcification is, at least in part, mediated through the inhibition of apoptosis and osteogenic differentiation via the GPR39-dependent ERK1/2 signaling pathway

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Our previous research demonstrated that the key cytosolic enzyme of the uronic acid pathway, UDP-glucose 6-dehydrogenase (UGDH), can inhibit TNF-induced cell death through its metabolic function, which is dependent of its metabolic substrate UDP-glucose 4

To minimize the formation of photoactive byproducts, the culture medium was replaced with Hanks Balanced Salt Solution (HBSS