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The Chiodo Brothers, that's who

The Wnt/-catenin signaling pathway is critical in pro-survival signaling leading to self-renewal and growth, and interactions with other survival pathways such as STAT, MAPK, and PI3K/Akt, which is implicated in treatment resistance to multiple modalities of therapy, such as chemotherapy, targeted therapy such as cetuximab, anti-PD1 immune checkpoint inhibitors, as well as radiotherapy (122)

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2.2.8 Forskolin Forskolin, a labdane diterpenoid derived from Plectranthus barbatus (formerly Coleus forskohlii ), is a direct activator of adenylyl cyclase, increasing intracellular cyclic AMP (cAMP) which play a crucial role in IOP regulation, neuroprotection, and cellular signaling (219221)

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doi: 10.1038/nchembio.2239 26 ChenXKangRKroemerGTangD