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On the other hand, FAO may also be related to macrophage polarization

In tumor tissues, mTORC1 phosphorylation was reduced, and AMPK phosphorylation and LC3BII/I ratios were decreased in the TER group compared to other tumor-bearing groups, suggesting that the combined therapy not only helped preserve muscle mass but also altered tumor metabolic signaling pathways in a favorable direction (88)

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Within the PPIs, k-means clustering of 78 nodes, 58 nodes fell within Cluster 1, 17 in Cluster 2, and 2 in Cluster 3 (Supplementary Table 3