Long-term pioglitazone treatment for patients with nonalcoholic steatohepatitis and prediabetes or type 2 diabetes mellitus: a randomized trial
Dr Juurlink suggests that any patient who meets the EXtracorporeal TReatments In Poisoning (ExTRIP) criteria for hemodialysis might be a candidate
At the cellular level, ALCAR acts as a critical shuttle for metabolic efficiency
PLoS ONE 9 , e97330 (2014)
2 Pathogenesis of IBD Since its emergence in the western world over a century ago, the epidemiology of IBD has undergone a significant shift ( 2.1 Dysbiosis of intestinal flora A reduction in the abundance and diversity of specific bacterial genera in the gut microbiota, as well as alterations in microbiota-derived metabolites, has been identified as a potential key factor in the pathogenesis of IBD ( Roseburia and Phascolarctobacterium , were markedly decreased in UC and CD patients in contrast to healthy people ( Roseburia is known for its role in promoting the generation of gut anti-inflammatory regulatory T cells ( Phascolarctobacterium metabolizes succinate to generate propionate when in co-culture with Paraprevotella ( Phascolarctobacterium populations in IBD patients may impair the production of propionate, thus diminishing the anti-inflammatory effects of SCFAs and contributing to the exacerbation of IBD symptoms
Amsterdam, Elsevier, pp 109118 Arduini A, Gorbunov N, Arrigoni-Martelli E, Dottori S, Molajoni F, Russo F, Federici G
