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The UPR and iron starvationlike responses were independent of each other, as the latter persisted in HGT1 ire1 cells that had otherwise lost the UPR (Supplementary Figure S4C and D), but their concurrence probably caused conflicting gene regulation

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Its depletion during illness or infection leads to intestinal epithelial cells atrophy resulting in increased intestinal permeability (352)

doi: 10.1039/D0FO00077A 110 JeongYJhunJYLeeSYNaHSChoiJWChoKHet al

doi: 10.3389/fncel.2025.1523773 20

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