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They are signaling molecules

Liver samples were deproteinized with a six-fold volume of cold acetonitrile (1:1 ratio), subjected to intermittent vortexing on ice for 30 min at 4 C, then centrifuged at 18,000 g

Women demonstrate lower prevalence of T2D and prediabetes in younger ages as well as decreased mortality due to diabetes compared to males despite higher BMI in women

de Souza JS, Ferreira DR, Herai R, Carromeu C, Torres LB, Araujo BHS, Cugola F, Maciel RMB, Muotri AR, Giannocco G

finally, in terms of limitations, it highlights the heterogeneity in evidence [e.g., variations in Omega-3 dosing across RCTs (65)] and population-specific biases [e.g., vitamin D studies focusing on IBD patients (169)]

DOI: 10.2174/157015909787602823 Dentico P, et al