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Nevertheless, there are studies providing evidence for an influence of circulating UA on the pathology and behaviour of animal models of PD independent of any humanising effects on uricase activity

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Indeed, the translocator protein (Tspo), a protein that binds to the voltage-dependent anion channel (VDAC) and interferes with redox balance 69,70,71 was upregulated after sUA+LPS stimulus in all macrophages analyzed, but in a more pronounced way in WT and Myd88 / cells