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3.6 Melanogenesis reduction Ultraviolet radiation stimulates melanogenesis through activation of the microphthalmia-associated transcription factor (MITF)-regulated pathway, promoting tyrosinase (TYR)-dependent melanin synthesis in melanosomes to protect against DNA damage, while excessive production leads to hyperpigmentation disorders (Kim et al., 2021)

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In contrast, the elevation in caudate Glx did not normalize after CBT in a similar population, despite clear symptomatic improvement (Benazon, Moore, & Rosenberg, 2003), suggesting (as had earlier studies using PET imaging of cerebral metabolism

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