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Notably, Nrf2/HO-1 inhibits the overexpression of the key inflammatory mediator cyclooxygenase-2 (COX-2), resulting in an anti-inflammatory effect

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After the numbing wears off there can be some tenderness that can be relieved by ibuprofen

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Statistical analysis Categorical variables were compared using Fishers exact test or 2 test, as appropriate, with the Bonferroni correction in post hoc analyses