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Before prescribing sildenafil, carefully consider whether patients with certain underlying conditions could be adversely affected by such vasodilatory effects (e.g., patients on antihypertensive therapy or with resting hypotension [blood pressure less than 90/50], fluid depletion, severe left ventricular outflow obstruction, or autonomic dysfunction)

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Conversely, inhibition of mitophagy can lead to mitochondrial dysfunction, trigger apoptosis, and ultimately increase treatment sensitivity [46]

This kind of systemsbased approach is particularly important for patients who have plateaued on conventional diets or have complex conditions like prediabetes, fatty liver, or chronic fatigue

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However, the use of combined therapies also increases adverse side effects (Mller, 2015)