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Finally, ROS and products of lipid peroxidation can lead to fibrosis by activating hepatic stellate cells, which synthesize collagen and perpetuate the inflammatory response.

10.1093/ndt/gfad238 27 JiaoY.HannafonN.DingW

i.e., LOX) enzymes also contributes to this process

Wu WK, Famure O, Li Y, Kim SJ

Their finding marked a decisive breakthrough because it challenged a long-standing belief that nerves controlled the secretion of digestive enzymes that had grown out of the work of Ivan Pavlov, the Russian physiologist who demonstrated that dogs can be conditioned to salivate by the sound of a bell (Rehfeld 2012)