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In idiopathic PAH, genes such as IGF1 and KARS participate in metabolic remodeling by regulating glycolysis in fibroblasts (Gao et al., 2025)

A striking example is curcumins synergy with antibiotics against resistant organisms: curcumin greatly improved the efficacy of polymyxin and vancomycin against both Gram-negative and Gram-positive pathogens by increasing cell membrane permeability and blocking drug efflux ( Candida (fungal) cells as wellcurcumin interacts with membrane ergosterol, akin to polyene antifungals, leading to membrane destabilization

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The proteins combination of proven efficacy, well-characterized mechanisms, favorable safety profile, and diverse delivery options creates a compelling foundation for clinical development

Nanoemulsion improves the neuroprotective effects of curcumin in an experimental model of Parkinson's disease