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Future studies need to include standardised techniques and analyses when doing further research into the virome as it is particularly understudied in ME/CFS ( External stressors like stressful or traumatic incidents, acute infection, and toxic stressors may result in widespread and chronic systemic and even neuroinflammation, driven by a variety of inflammatory molecules in circulation

Nevertheless, it can be hypothesized, that the whole PBMC population was experiencing metabolic stress by LPS addition in the present study, which may be the reason for decreased OCR

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doi: 10.1080/19490976.2018.1474322 222 WagnerJMaksimovicJFarriesGSimWHBishopRFCameronDJet al

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