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Autophagy, on the one hand, can degrade damaged organelles and peroxidation products and act as an essential protective mechanism to maintain redox balance

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Immune cells and metabolites produced by gut bacteria can move through the circulatory system to stimulate immune responses in the lungs, while the lung microbiota can induce microbial changes in the blood and gut ( 2 Microbiota and COPD 2.1 Lung microbiota and COPD Traditionally, lungs are considered sterile spaces, but in fact, they have their own microbial community composed of bacteria, viruses, and fungi ( Proteobacteria, Firmicutes, and Bacteroidetes are the most common genera in COPD patients, while at the genus level, Pseudomonas, Streptococcus, Prevotella, Fusobacteria, and Veillonella are the main genera

4.2 Alkaloids Alkaloids represent a group of low molecular weight secondary metabolites which contain a nitrogen group and are reported to possess gastroprotective activity [119]

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Ferredoxin-dependent pathways may be important in TRX and MDHA reduction in the chloroplast