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The differentiation of Cth -deficient preadipocytes to mature adipocytes and subsequent exposure to cysteine-free culture conditions did not affect their thermogenic genes or UCP1, suggesting that a non-cell autonomous mechanism may control adipocyte browning (Extended Data Fig

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109 mg/dL, p =3.6x10 -06 ) and total cholesterol level (119 mg/dL vs

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Herein, immunofluorescence studies further showed that GMSCs displayed a significant increase in the protein expression of S-100 and p75 NTR , two common markers for Schwann cell precursors [43] when they were encapsulated and cultured in the methacrylated 3D-collagen hydrogel at a concentration of 4 mg/mL for 48 h compared to their counterparts under 2D-culture conditions (Fig