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The brain substantia nigra in PD has a high level of expression of the VD metabolizing enzyme and 1 hydroxylase, and VD can stimulate the expression of tyrosine hydroxylase, a key enzyme of dopamine synthesis in PD, which affects the production and turnover of dopamine, therefore, the role of VD in the development process of PD has received increasing attention (85, 86)

No apparent cause for the patients status epilepticus

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A clear definition of moderate versus 'severe and acute as opposed to 'chronic water deficit is necessary for a meaningful interpretation of multiple studies on drought-mediated effects (Caldeira 2019