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Lipopolysaccharide (LPS) binding to Toll-like receptor 4 (TLR4) on immune cells not only activates nuclear factor NF-B (NF-B) but also generates ROS that activate NADPH oxidase

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In this study, we investigated the time-dependent decrease in reducing activity of DTT during prolonged protein synthesis using the PURE system

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It is also a co-factor for GPX4-mediated lipid detoxification 35 , and GPX4 activity is necessary for the survival of several tissues, including the liver 36 and kidney 37

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Bastianetto S, Quirion R (2004) Natural antioxidants and neurodegenerative diseases

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