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9 Comparative and synergistic analysis of Rhodiola rosea , Ginkgo biloba , and Ashwagandha Rhodiola rosea , Ginkgo biloba , and Withania somnifera (Ashwagandha) represent three botanically and pharmacologically distinct interventions that converge on core pathophysiological mechanisms of depressive disorders while maintaining clearly differentiable profiles across pharmacodynamics, pharmacokinetics, clinical efficacy, and safety