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Taking these findings into account, along with the elevated subclinical gut inflammation and intestinal permeability observed during earlier studies involving patients with rheumatic disease, it can be proposed that gut-joint communication plays an important role in AD development (Mielants et al

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Comment: Several commenters suggested the proposal is methodologically flawed and not proportional to the issue it seeks to address

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First, our enteric nervous system (ENS), which is located throughout our gastrointestinal tract, helps control our same chemicals and cells as the brain to help us digest and to alert the brain when something is amiss (Ruder, 2017)

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