glutathione conjugation problem of to a generic xenobiotic (X) via catalysis by Formation of mercapturic acid. Glutathione

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Microcytic (mk) mice and sex-linked anemia (sla) mice have severe iron deficiency due apparently to defects in iron uptake and release, respectively, from the intestinal cell (reviewed in [Bannerman, 1976].) Mice with the homozygous autosomal recessive mk mutation absorb iron poorly, have low serum iron levels, and lack stainable iron in intestinal mucosal cells

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Zoref-Shani E, Bromberg Y, Lilling G et al (1995) Developmental changes in purine nucleotide metabolism in cultured rat astroglia

For this reason, prebiotics, probiotics and synbiotics could be considered as treatment of PCOS to regulate gut microbiota [42]