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Experiments have shown that 252 the accumulation of lactate in the TME entails acidification of the TME, and a lower extracellular pH has been shown to impair almost all aspects of CD8 + and CD4 + T lymphocyte function, including the activation of cytotoxicity, chemotactic motility, and proliferation 253,254

They provide multiple avenues through which changes in the gut microbiome can influence central processes relevant to neurodegeneration (and vice versa)

The use of human MNCs was approved by the Ethics Committee of Kiel University under informed consent from healthy donors

SJ Padayatty, AY Sun, Q Chen, et al

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