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Furthermore, its potential in treating various diseases, particularly neurodegenerative and respiratory diseases, requires further investigation

The information on medication with potential effects on different metabolic pathways is summarized in Table 2

Finally, they reflect pathways likely additional to those involved in the angiogenesis (Vukojevic et al., 2018), recently associated in particular with the increased expression, internalization of VEGFR2, and the activation of the VEGFR2-Akt-eNOS signaling pathway (Hsieh et al., 2017) (see Genes Expression as Support ), given the rapid presentation of all of these effects, which occurred before the process of angiogenesis could be initiated (Sikiric et al., 1993

The present study aims at identifying key metabolites and metabolic pathways of IHD that may allow for an earlier intervention and/or a more effective approach to treatment

[PubMed: 22085343] 733

Comparative evaluation of effect of potassium iodide and glutathione on tooth discoloration after application of 38% silver diamine fluoride in primary molars:An in vitro study