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However, the use of nanoparticles for the treatment of CNS diseases still has several issues that are yet to be resolved

These pharmacokinetic differences inform the trade-offs in onset, convenience, and dosing convenience

The composition of this solution was approximately 16% Poloxamer 407, 0.30% tromethamine, 0.22% sodium chloride

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The extracellular region of c-MET has high affinity toward HGF while the single transmembrane segment and the cytoplasmic tyrosine kinase domain is edged by juxtamembrane and carboxy-terminal sequences

Safety and translational considerations were discussed, including brain penetration after systemic administration