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Typically, patients suffering from UC exhibit a range of clinical symptoms, which encompass abdominal pain, persistent diarrhea, rectal bleeding, as well as unintended weight loss (Krugliak Cleveland et al., 2022)

Presently various components associated with ROS-induced signalling cascades have been well identified

Pharmacological manipulation with AQP4 function or expression holds promise in several clinical settings but might have side effects that deserve careful consideration

Ethics declarations Ethics approval and consent to participate All animal experimental protocols in this study were approved by the Animal Ethics Committee of Gansu Agricultural University (approval number GAU-LC-2020-014) and strictly implemented in accordance with guidelines

Comparative effects of the antimycotic drugs ketoconazole, fluconazole, itraconazole and terbinafine on the metabolism of cyclosporin by human liver microsomes