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Cell targeting may reduce off-target accumulation of nanoparticles that can potentially occur after intra-articular injection in diseased joints

2014 Aug;73:127-35

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When compared to matched normal thyroid tissue, both benign (human follicular adenomas, or FTAs) and malignant (follicular (FTC) and papillary thyroid carcinoma (PTC)) lesions were found to have elevated nuclear levels of 8-oxo-dG (118) which most likely reflects the detrimental effects of prolonged exposure to chronic OxS seen during thyroid cancer (113, 118)

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This reduction in cytokine release likely occurs due to inhibited NF-B signalling, as intermediates of the NF-B pathway such as phosphorylated p-65 and phosphorylated NF-B are decreased upon Hcar2 agonism [81, 82]