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The abundance of natural 13 C-labeled metabolite in ARP1 cells cultured with 13 C 2 -glycine was calculated by the following formula: abundance of natural 13 C-labeled metabolite = abundance of non 13 C-labeled metabolite P 0

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BPTES) or SLC1A5 (GPNA), the key enzyme and glutamine transporter whose activities are crucial for the process ( Figure 4a ), substantially rescued the viability of Erastin-treated LDHB KD A549 cells ( Figure 4e ), indicating that LDHB KD/Erastin inhibits cell viability through glutaminolysis

2 Pathophysiology of rheumatoid arthritis RA is primarily characterized by hyperplasia and inflammation of the synovium, leading to progressive destruction of cartilage and bone

Comparisons among groups were performed by the Students t -test or one-way analysis of variance (ANOVA) followed by the Tukey test, while for multiple comparisons, Graph-Pad Prism analysis software (Graph-Pad Software, San Diego, CA) was applied

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