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Underventilation or apnea due to unintentional subarachnoid injection of local anesthetic solution may produce these same signs and also lead to cardiac arrest if ventilatory support is not instituted

There is no human trial, no combination safety study, and no convincing animal study of the pair [2]

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doi:10.1002/14651858.CD011790.pub2

For example, hypofractionated radiation was shown to be more immunogenic compared to a single high dose in breast cancer and was shown to sensitize mice with breast cancer, melanoma, colon carcinoma or pancreatic cancer to ICI (336340)

Identifying deficiencies or surplus levels promptly can prevent complications like clotting or extreme anemia